6VQA
Mammalian V-ATPase from rat brain soluble V1 region rotational state 2 with SidK and ADP (from focused refinement)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C | ATPase H+-transporting V1 subunit A | polymer | 617 | 68341.8 | 3 | UniProt (D4A133) Pfam (PF02874) Pfam (PF16886) Pfam (PF00006) In PDB | Rattus norvegicus (Rat) | RCG52629 |
| 2 | D, E, F | V-type proton ATPase subunit B, brain isoform | polymer | 511 | 56611.6 | 3 | UniProt (P62815) Pfam (PF02874) Pfam (PF00006) In PDB | Rattus norvegicus (Rat) | V-ATPase subunit B 2,Endomembrane proton pump 58 kDa subunit,Vacuolar proton pump subunit B 2 |
| 3 | H | ATPase H+-transporting V1 subunit D | polymer | 247 | 28359.0 | 1 | UniProt (Q6P503) Pfam (PF01813) In PDB | Rattus norvegicus (Rat) | ATPase,H+ transporting,V1 subunit D,isoform CRA_c,lysosomal V1 subunit D |
| 4 | I, J, K | V-type proton ATPase subunit E 1 | polymer | 226 | 26167.5 | 3 | UniProt (Q6PCU2) Pfam (PF01991) In PDB | Rattus norvegicus (Rat) | V-ATPase subunit E 1,Vacuolar proton pump subunit E 1 |
| 5 | M, N, O | V-type proton ATPase subunit G | polymer | 118 | 13690.5 | 3 | UniProt (Q8R2H0) Pfam (PF03179) In PDB | Rattus norvegicus (Rat) | |
| 6 | Q, R, S | Effector protein SidK | polymer | 301 | 34693.6 | 3 | UniProt (Q5ZWW6) In PDB | Legionella pneumophila subsp. pneumophila (strain Philadelphia 1 / ATCC 33152 / DSM 7513) | |
| 7 | B | ADENOSINE-5'-DIPHOSPHATE | non-polymer | 427.2 | 1 | Chemie (ADP) | |||
| 8 | B | MAGNESIUM ION | non-polymer | 24.3 | 1 | Chemie (MG) |
Sequence modifications
Q, R, S: 1 - 278 (UniProt: Q5ZWW6)
| PDB | External Database | Details |
|---|---|---|
| Gly 0 | - | expression tag |
| Asp 279 | - | expression tag |
| Tyr 280 | - | expression tag |
| Lys 281 | - | expression tag |
| Asp 282 | - | expression tag |
| His 283 | - | expression tag |
| Asp 284 | - | expression tag |
| Gly 285 | - | expression tag |
| Asp 286 | - | expression tag |
| Tyr 287 | - | expression tag |
| Lys 288 | - | expression tag |
| Asp 289 | - | expression tag |
| His 290 | - | expression tag |
| Asp 291 | - | expression tag |
| Ile 292 | - | expression tag |
| Asp 293 | - | expression tag |
| Tyr 294 | - | expression tag |
| Lys 295 | - | expression tag |
| Asp 296 | - | expression tag |
| Asp 297 | - | expression tag |
| Asp 298 | - | expression tag |
| Asp 299 | - | expression tag |
| Lys 300 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 16 |
| Total formula weight | 626873.8 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 451.5 | |
| All* | Total formula weight | 627325.3 |
