6VAX

Crystal structure of human SDHA-SDHAF2 assembly intermediate

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, C	Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial	polymer	632	69416.4	2	UniProt (P31040) Pfam (PF00890) Pfam (PF02910) In PDB	Homo sapiens (Human)	Flavoprotein subunit of complex II,Fp
2	B, D	Succinate dehydrogenase assembly factor 2, mitochondrial	polymer	166	19626.4	2	UniProt (Q9NX18) Pfam (PF03937) In PDB	Homo sapiens (Human)	SDHAF2
3	A, C	FLAVIN-ADENINE DINUCLEOTIDE	non-polymer		785.5	2	Chemie (FAD)
4	A, C	OXALOACETATE ION	non-polymer		131.1	2	Chemie (OAA)
5	A	MALONATE ION	non-polymer		102.0	1	Chemie (MLI)
6	A, C	GLYCEROL	non-polymer		92.1	2	Chemie (GOL)
7	A, C	POTASSIUM ION	non-polymer		39.1	2	Chemie (K)
8	A, C	1,2-ETHANEDIOL	non-polymer		62.1	9	Chemie (EDO)
9		water	water		18.0	99	Chemie (HOH)

Sequence modifications

A, C: 44 - 664 (UniProt: P31040)

PDB	External Database	Details
Met 33	-	expression tag
Arg 34	-	expression tag
Gly 35	-	expression tag
Ser 36	-	expression tag
His 37	-	expression tag
His 38	-	expression tag
His 39	-	expression tag
His 40	-	expression tag
His 41	-	expression tag
His 42	-	expression tag
Gly 43	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	178085.7
Non-Polymers*	Number of molecules	18
	Total formula weight	2756.3
All*	Total formula weight	180842.0

*Water molecules are not included.