6V4X
Cryo-EM structure of an active human histone pre-mRNA 3'-end processing machinery at 3.2 Angstrom resolution
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Small nuclear ribonucleoprotein Sm D3 | polymer | 146 | 16111.7 | 1 | UniProt (P62318) Pfam (PF01423) In PDB | Homo sapiens (Human) | Sm-D3,snRNP core protein D3 |
2 | B | Small nuclear ribonucleoprotein-associated proteins B and B' | polymer | 95 | 10911.9 | 1 | UniProt (P14678) Pfam (PF01423) In PDB | Homo sapiens (Human) | snRNP-B,Sm protein B/B',SmB/B' |
3 | F | Small nuclear ribonucleoprotein F | polymer | 86 | 9734.2 | 1 | UniProt (P62306) Pfam (PF01423) In PDB | Homo sapiens (Human) | snRNP-F,Sm protein F,SmF |
4 | E | Small nuclear ribonucleoprotein E | polymer | 92 | 10817.6 | 1 | UniProt (P62304) Pfam (PF01423) In PDB | Homo sapiens (Human) | snRNP-E,Sm protein E,SmE |
5 | G | Small nuclear ribonucleoprotein G | polymer | 84 | 9579.2 | 1 | UniProt (P62308) Pfam (PF01423) In PDB | Homo sapiens (Human) | snRNP-G,Sm protein G,SmG |
6 | C | U7 snRNA-associated Sm-like protein LSm10 | polymer | 123 | 14102.1 | 1 | UniProt (Q969L4) Pfam (PF01423) In PDB | Homo sapiens (Human) | |
7 | D | U7 snRNA-associated Sm-like protein LSm11 | polymer | 259 | 28609.8 | 1 | UniProt (P83369) In PDB | Homo sapiens (Human) | |
8 | H | Cleavage and polyadenylation specificity factor subunit 3 | polymer | 684 | 77580.9 | 1 | UniProt (Q9UKF6) Pfam (PF11718) Pfam (PF16661) Pfam (PF10996) Pfam (PF07521) In PDB | Homo sapiens (Human) | Cleavage and polyadenylation specificity factor 73 kDa subunit,CPSF 73 kDa subunit,mRNA 3'-end-processing endonuclease CPSF-73 |
9 | I | Cleavage and polyadenylation specificity factor subunit 2 | polymer | 782 | 88597.7 | 1 | UniProt (Q9P2I0) Pfam (PF16661) Pfam (PF10996) Pfam (PF07521) Pfam (PF13299) In PDB | Homo sapiens (Human) | Cleavage and polyadenylation specificity factor 100 kDa subunit,CPSF 100 kDa subunit |
10 | J | Symplekin | polymer | 1072 | 120355.1 | 1 | UniProt (Q92797) Pfam (PF11935) Pfam (PF12295) In PDB | Homo sapiens (Human) | |
11 | Z | U7 snRNA | polymer | 60 | 19097.2 | 1 | GenBank (1633547) | Homo sapiens | |
12 | Y | modified H2a pre-mRNA | polymer | 52 | 16627.0 | 1 | Mus musculus | ||
13 | H | ZINC ION | non-polymer | 65.4 | 2 | Chemie (ZN) |
Sequence modifications
A: 1 - 126 (UniProt: P62318)
G: 1 - 76 (UniProt: P62308)
D: 1 - 322 (UniProt: P83369)
D: 323 - 360 (UniProt: P83369)
PDB | External Database | Details |
---|---|---|
Met -19 | - | expression tag |
Gly -18 | - | expression tag |
Ser -17 | - | expression tag |
Ser -16 | - | expression tag |
His -15 | - | expression tag |
His -14 | - | expression tag |
His -13 | - | expression tag |
His -12 | - | expression tag |
His -11 | - | expression tag |
His -10 | - | expression tag |
Ser -9 | - | expression tag |
Ser -8 | - | expression tag |
Gly -7 | - | expression tag |
Leu -6 | - | expression tag |
Val -5 | - | expression tag |
Pro -4 | - | expression tag |
Arg -3 | - | expression tag |
Gly -2 | - | expression tag |
Ser -1 | - | expression tag |
His 0 | - | expression tag |
PDB | External Database | Details |
---|---|---|
Leu 77 | - | expression tag |
Glu 78 | - | expression tag |
His 79 | - | expression tag |
His 80 | - | expression tag |
His 81 | - | expression tag |
His 82 | - | expression tag |
His 83 | - | expression tag |
His 84 | - | expression tag |
PDB | External Database | Details |
---|---|---|
Met -10 | - | expression tag |
His -9 | - | expression tag |
His -8 | - | expression tag |
His -7 | - | expression tag |
His -6 | - | expression tag |
His -5 | - | expression tag |
His -4 | - | expression tag |
Ser -3 | - | expression tag |
Gly -2 | - | expression tag |
Gly -1 | - | expression tag |
Ser 0 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 12 |
Total formula weight | 422124.4 | |
Non-Polymers* | Number of molecules | 2 |
Total formula weight | 130.8 | |
All* | Total formula weight | 422255.2 |