6V2F
Crystal structure of the HIV capsid hexamer bound to the small molecule long-acting inhibitor, GS-6207
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D, E... | HIV-1 capsid | polymer | 232 | 25592.5 | 6 | UniProt (B6DRA0) Pfam (PF00607) Pfam (PF19317) UniProt (by SIFTS) (P12493) In PDB | Human immunodeficiency virus 1 | |
| 2 | A, B, C, D, E... | N-[(1S)-1-(3-{4-chloro-3-[(methylsulfonyl)amino]-1-(2,2,2-trifluoroethyl)-1H-indazol-7-yl}-6-[3-methyl-3-(methylsulfonyl)but-1-yn-1-yl]pyridin-2-yl)-2-(3,5-difluorophenyl)ethyl]-2-[(3bS,4aR)-5,5-difluoro-3-(trifluoromethyl)-3b,4,4a,5-tetrahydro-1H-cyclopropa[3,4]cyclopenta[1,2-c]pyrazol-1-yl]acetamide | non-polymer | 968.3 | 6 | Chemie (QNG) | |||
| 3 | water | water | 18.0 | 851 | Chemie (HOH) |
Sequence modifications
A, B, C, D, E, F: 1 - 231 (UniProt: B6DRA0)
| PDB | External Database | Details |
|---|---|---|
| Met 0 | - | initiating methionine |
| Cys 14 | Ala 146 | conflict |
| Cys 45 | Glu 177 | conflict |
| Ala 184 | Trp 316 | conflict |
| Ala 185 | Met 317 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 153554.8 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 5809.7 | |
| All* | Total formula weight | 159364.5 |
