6U39

2.4 Angstrom crystal structure of the D129G Ca-CaM:CaV1.2 IQ domain complex

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, C, E, G, I...	Calmodulin-1	polymer	148	16663.3	10	UniProt (P0DP23) Pfam (PF13499) In PDB	Homo sapiens (Human)
2	B, D, F, H, J...	Voltage-dependent L-type calcium channel subunit alpha-1C	polymer	37	4319.0	10	UniProt (Q13936) In PDB	Homo sapiens (Human)	Calcium channel, L type, alpha-1 polypeptide, isoform 1, cardiac muscle, Voltage-gated calcium channel subunit alpha Cav1.2
3	E, G, I, K, M...	CALCIUM ION	non-polymer		40.1	29	Chemie (CA)
4		water	water		18.0	20	Chemie (HOH)

Sequence modifications

A, C, E, G, I, K, M, O, Q, S: 1 - 148 (UniProt: P0DP23)

PDB	External Database	Details
Gly 129	Asp 130	engineered mutation

B, D, F, H, J, L, N, P, R, T: 1611 - 1644 (UniProt: Q13936)

PDB	External Database	Details
Ser 1608	-	expression tag
Asn 1609	-	expression tag
Ala 1610	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	20
	Total formula weight	209822.8
Non-Polymers*	Number of molecules	29
	Total formula weight	1162.3
All*	Total formula weight	210985.1

*Water molecules are not included.