6TYS
A potent cross-neutralizing antibody targeting the fusion glycoprotein inhibits Nipah virus and Hendra virus infection
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, E | Fusion glycoprotein F0 | polymer | 538 | 59704.8 | 3 | UniProt (Q9IH63) Pfam (PF00523) In PDB | Nipah virus | Protein F |
| 2 | H, C, F | 5B3 antibody heavy chain | polymer | 120 | 13245.8 | 3 | Mus musculus (Mouse) | ||
| 3 | L, D, G | 5B3 antibody light chain | polymer | 107 | 11517.8 | 3 | Mus musculus (Mouse) | ||
| 4 | I, M, N, Q, R... | alpha-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 586.5 | 6 | In PDB GlyTouCan (G62182OO) | |||
| 5 | J, O, S | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 3 | In PDB GlyTouCan (G42666HT) | |||
| 6 | K, P, T | alpha-D-mannopyranose-(1-2)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose | branched | 504.4 | 3 | In PDB GlyTouCan (G04118VH) | |||
| 7 | E, A, B | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 6 | Chemie (NAG) |
Sequence modifications
A, B, E: 1 - 494 (UniProt: Q9IH63)
A, B, E: 495 - 530 (PDB: 6TYS)
| PDB | External Database | Details |
|---|---|---|
| Cys 100 | Asn 100 | conflict |
| Asp 104 | - | insertion |
| Tyr 104 | - | insertion |
| Lys 104 | - | insertion |
| Asp 104 | - | insertion |
| Asp 104 | - | insertion |
| Asp 104 | - | insertion |
| Asp 104 | - | insertion |
| Lys 104 | - | insertion |
| Cys 119 | Ala 119 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 9 |
| Total formula weight | 253405.1 | |
| Branched | Number of molecules | 12 |
| Total formula weight | 6305.8 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 1327.2 | |
| All* | Total formula weight | 261038.1 |
