6TWI
Crystal structure of the haemagglutinin mutant (Gln226Leu, Gly228Ser) from an H10N7 seal influenza virus isolated in Germany in complex with avian receptor analogue 3'-SLN
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, C, E | Hemagglutinin | polymer | 325 | 35514.1 | 3 | UniProt (A0A0A7HR51) Pfam (PF00509) In PDB | Influenza A virus (A/harbour seal/Germany/1/2014(H10N7)) | |
2 | B, D, F | Hemagglutinin HA2 | polymer | 177 | 20313.4 | 3 | UniProt (A0A0A7HR51) Pfam (PF00509) In PDB | Influenza A virus (A/harbour seal/Germany/1/2014(H10N7)) | |
3 | G, H, J | N-acetyl-alpha-neuraminic acid-(2-3)-beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 674.6 | 3 | In PDB BIRD (PRD_900067) GlyTouCan (G00065MO) | 3'-sialyl-N-acetyllactosamine | ||
4 | I | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 1 | In PDB GlyTouCan (G42666HT) | |||
5 | A, B, C, E, F | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 5 | Chemie (NAG) | |||
6 | A, B, C | 1,2-ETHANEDIOL | non-polymer | 62.1 | 4 | Chemie (EDO) | |||
7 | A, C, E | CALCIUM ION | non-polymer | 40.1 | 3 | Chemie (CA) | |||
8 | water | water | 18.0 | 497 | Chemie (HOH) |
Sequence modifications
A, C, E: 1 - 323 (UniProt: A0A0A7HR51)
B, D, F: 1 - 176 (UniProt: A0A0A7HR51)
PDB | External Database | Details |
---|---|---|
Asp -1 | - | expression tag |
Pro 0 | - | expression tag |
Ser 221 | Gly 230 | engineered mutation |
PDB | External Database | Details |
---|---|---|
Lys 177 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 6 |
Total formula weight | 167482.6 | |
Branched | Number of molecules | 4 |
Total formula weight | 2448.2 | |
Non-Polymers* | Number of molecules | 12 |
Total formula weight | 1474.5 | |
All* | Total formula weight | 171405.3 |