6TOL
Crystal structure of human BCL6 BTB domain in complex with compound 25a
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | B-cell lymphoma 6 protein | polymer | 144 | 16499.0 | 1 | UniProt (P41182) Pfam (PF00651) In PDB | Homo sapiens (Human) | BCL-6,B-cell lymphoma 5 protein,BCL-5,Protein LAZ-3,Zinc finger and BTB domain-containing protein 27,Zinc finger protein 51 |
2 | A | 5-[[5-chloranyl-2-[(2~{S},6~{R})-2,6-dimethylmorpholin-4-yl]pyrimidin-4-yl]amino]-1-methyl-3-(3-methyl-3-oxidanyl-butyl)benzimidazol-2-one | non-polymer | 475.0 | 1 | Chemie (NQW) | |||
3 | A | 1,2-ETHANEDIOL | non-polymer | 62.1 | 8 | Chemie (EDO) | |||
4 | A | DIMETHYL SULFOXIDE | non-polymer | 78.1 | 1 | Chemie (DMS) | |||
5 | water | water | 18.0 | 161 | Chemie (HOH) |
Sequence modifications
A: 5 - 129 (UniProt: P41182)
PDB | External Database | Details |
---|---|---|
Gly -14 | - | expression tag |
Pro -13 | - | expression tag |
Gly -12 | - | expression tag |
Leu -11 | - | expression tag |
Asp -10 | - | expression tag |
Tyr -9 | - | expression tag |
Lys -8 | - | expression tag |
Asp -7 | - | expression tag |
Asp -6 | - | expression tag |
Asp -5 | - | expression tag |
Asp -4 | - | expression tag |
Lys -3 | - | expression tag |
Glu -2 | - | expression tag |
Asn -1 | - | expression tag |
Leu 0 | - | expression tag |
Tyr 1 | - | expression tag |
Phe 2 | - | expression tag |
Gln 3 | - | expression tag |
Gly 4 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 1 |
Total formula weight | 16499.0 | |
Non-Polymers* | Number of molecules | 10 |
Total formula weight | 1049.7 | |
All* | Total formula weight | 17548.6 |