6T6J

Crystal Structure of the C-terminal domain of the HIV-1 Integrase (subtype A2, mutant N254K, K340Q)

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C	Pol protein	polymer	59	7053.2	3	UniProt (A0A290WA76) Pfam (PF00552) UniProt (by SIFTS) (Q75002) In PDB	Human immunodeficiency virus 1
2	A	NICKEL (II) ION	non-polymer		58.7	2	Chemie (NI)
3		water	water		18.0	94	Chemie (HOH)

Sequence modifications

A, B, C: 219 - 270 (UniProt: A0A290WA76)

PDB	External Database	Details
Met 212	-	initiating methionine
Gly 213	-	expression tag
His 214	-	expression tag
His 215	-	expression tag
His 216	-	expression tag
His 217	-	expression tag
His 218	-	expression tag
Gln 240	Lys 241	engineered mutation
Lys 254	Asn 255	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	3
	Total formula weight	21159.5
Non-Polymers*	Number of molecules	2
	Total formula weight	117.4
All*	Total formula weight	21276.9

*Water molecules are not included.