6T2D
Multicomponent Peptide Stapling as a Diversity-Driven Tool for the Development of Inhibitors of Protein-Protein Interactions
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | E3 ubiquitin-protein ligase Mdm2 | polymer | 86 | 10192.0 | 1 | UniProt (Q00987) Pfam (PF02201) In PDB | Homo sapiens (Human) | Double minute 2 protein,Hdm2,Oncoprotein Mdm2,RING-type E3 ubiquitin transferase Mdm2,p53-binding protein Mdm2 |
| 2 | B | Stapled peptide GAR300-Gp | polymer | 14 | 1656.8 | 1 | synthetic construct | ||
| 3 | A | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID | non-polymer | 238.3 | 1 | Chemie (EPE) | |||
| 4 | A | DIMETHYL SULFOXIDE | non-polymer | 78.1 | 1 | Chemie (DMS) | |||
| 5 | B | 2-(methylamino)-~{N}-[[4-[[2-(methylamino)ethanoylamino]methyl]phenyl]methyl]ethanamide | non-polymer | 278.4 | 1 | Chemie (M9E) | |||
| 6 | water | water | 18.0 | 124 | Chemie (HOH) |
Sequence modifications
A: 25 - 109 (UniProt: Q00987)
| PDB | External Database | Details |
|---|---|---|
| Met 24 | - | initiating methionine |
| Glu 33 | Leu 33 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 11848.8 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 594.8 | |
| All* | Total formula weight | 12443.6 |
