6RPS
X-ray crystal structure of carbonic anhydrase XII complexed with a theranostic monoclonal antibody fragment
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | Carbonic anhydrase 12 | polymer | 283 | 31605.0 | 2 | UniProt (O43570) Pfam (PF00194) In PDB | Homo sapiens (Human) | Carbonate dehydratase XII,Carbonic anhydrase XII,CA-XII,Tumor antigen HOM-RCC-3.1.3 |
2 | M, L | Fab Light chain | polymer | 216 | 23573.1 | 2 | Homo sapiens (Human) | ||
3 | N, H | Fab Heavy chain | polymer | 229 | 24663.5 | 2 | Homo sapiens (Human) | ||
4 | A, B | ZINC ION | non-polymer | 65.4 | 2 | Chemie (ZN) | |||
5 | A, B | ACETATE ION | non-polymer | 59.0 | 2 | Chemie (ACT) | |||
6 | A, N | SULFATE ION | non-polymer | 96.1 | 2 | Chemie (SO4) | |||
7 | A, B | CADMIUM ION | non-polymer | 112.4 | 4 | Chemie (CD) | |||
8 | A | CHLORIDE ION | non-polymer | 35.5 | 1 | Chemie (CL) | |||
9 | water | water | 18.0 | 23 | Chemie (HOH) |
Sequence modifications
A, B: 4 - 262 (UniProt: O43570)
PDB | External Database | Details |
---|---|---|
Met 3 | - | initiating methionine |
Gly 263 | - | expression tag |
Gly 264 | - | expression tag |
Gly 265 | - | expression tag |
Gly 266 | - | expression tag |
Ser 267 | - | expression tag |
Gly 268 | - | expression tag |
Gly 269 | - | expression tag |
Gly 270 | - | expression tag |
Gly 271 | - | expression tag |
Ser 272 | - | expression tag |
Gly 273 | - | expression tag |
Gly 274 | - | expression tag |
Gly 275 | - | expression tag |
Gly 276 | - | expression tag |
Ser 277 | - | expression tag |
His 278 | - | expression tag |
His 279 | - | expression tag |
His 280 | - | expression tag |
His 281 | - | expression tag |
His 282 | - | expression tag |
His 283 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 6 |
Total formula weight | 159683.2 | |
Non-Polymers* | Number of molecules | 11 |
Total formula weight | 926.1 | |
All* | Total formula weight | 160609.4 |