6QFC
Structure of an anti-Mcl1 scFv
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Induced myeloid leukemia cell differentiation protein Mcl-1 | polymer | 162 | 18227.6 | 1 | UniProt (Q07820) Pfam (PF00452) In PDB | Homo sapiens (Human) | Bcl-2-like protein 3,Bcl2-L-3,Bcl-2-related protein EAT/mcl1,mcl1/EAT |
| 2 | B | scFv55 | polymer | 255 | 26429.0 | 1 | Homo sapiens | ||
| 3 | A, B | DIMETHYL SULFOXIDE | non-polymer | 78.1 | 5 | Chemie (DMS) | |||
| 4 | water | water | 18.0 | 248 | Chemie (HOH) |
Sequence modifications
A: 174 - 327 (UniProt: Q07820)
| PDB | External Database | Details |
|---|---|---|
| Gly 166 | - | expression tag |
| Pro 167 | - | expression tag |
| Leu 168 | - | expression tag |
| Gly 169 | - | expression tag |
| Ser 170 | - | expression tag |
| Glu 171 | - | expression tag |
| Asp 172 | - | expression tag |
| Asp 173 | - | expression tag |
| Ser 193 | Ala 193 | conflict |
| Ser 196 | Thr 196 | conflict |
| Leu 199 | Met 199 | conflict |
| Glu 201 | Arg 201 | conflict |
| Ala 202 | Ser 202 | conflict |
| Ala 205 | Thr 205 | conflict |
| Gly 206 | Ser 206 | conflict |
| Arg 208 | Lys 208 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 44656.6 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 390.7 | |
| All* | Total formula weight | 45047.2 |
