6Q6F
Crystal structure of IDH1 R132H in complex with HMS101
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | Isocitrate dehydrogenase [NADP] cytoplasmic | polymer | 414 | 46701.2 | 2 | UniProt (O75874) Pfam (PF00180) In PDB | Homo sapiens (Human) | IDH,Cytosolic NADP-isocitrate dehydrogenase,IDP,NADP(+)-specific ICDH,Oxalosuccinate decarboxylase |
2 | A, B | (2~{R})-2-[2-[(3~{R})-3-(4-fluorophenyl)pyrrolidin-1-yl]ethyl]-1,4-dimethyl-piperazine | non-polymer | 305.4 | 2 | Chemie (HJQ) |
Sequence modifications
A, B: 1 - 414 (UniProt: O75874)
PDB | External Database | Details |
---|---|---|
His 132 | Arg 132 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 93402.4 | |
Non-Polymers* | Number of molecules | 2 |
Total formula weight | 610.9 | |
All* | Total formula weight | 94013.2 |