6PUW

Structure of HIV cleaved synaptic complex (CSC) intasome bound with magnesium and Bictegravir (BIC)

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D	Chimeric Sso7d and HIV-1 integrase	polymer	383	42321.3	4	UniProt (P39476) UniProt (Q76353) Pfam (PF02294) Pfam (PF02022) Pfam (PF00665) Pfam (PF00552) UniProt (by SIFTS) (P12497) In PDB	Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)	7 kDa DNA-binding protein d,Sso7d
2	E	viral DNA non-transferred strand	polymer	27	8188.3	1		Human immunodeficiency virus 1
3	F	viral DNA transferred strand	polymer	25	7773.0	1		Human immunodeficiency virus 1
4	A	MAGNESIUM ION	non-polymer		24.3	2	Chemie (MG)
5	A, B	ZINC ION	non-polymer		65.4	2	Chemie (ZN)
6	A	Bictegravir	non-polymer		449.4	1	Chemie (KLQ)
7		water	water		18.0	156	Chemie (HOH)

Sequence modifications

A, B, C, D: -74 - -11 (UniProt: P39476)

PDB	External Database	Details
Met -94	-	expression tag
Gly -93	-	expression tag
Ser -92	-	expression tag
Ser -91	-	expression tag
His -90	-	expression tag
His -89	-	expression tag
His -88	-	expression tag
His -87	-	expression tag
His -86	-	expression tag
His -85	-	expression tag
Ser -84	-	expression tag
Ser -83	-	expression tag
Gly -82	-	expression tag
Leu -81	-	expression tag
Val -80	-	expression tag
Pro -79	-	expression tag
Arg -78	-	expression tag
Gly -77	-	expression tag
Ser -76	-	expression tag
His -75	-	expression tag
Gly -10	-	linker
Gly -9	-	linker
Gly -8	-	linker
Gly -7	-	linker
Gly -6	-	linker
Gly -5	-	linker
Gly -4	-	linker
Gly -3	-	linker
Gly -2	-	linker
Gly -1	-	linker
Gly 0	-	linker

A, B, C, D: 1 - 288 (UniProt: Q76353)

Contents of the asymmetric unit

Polymers	Number of chains	6
	Total formula weight	185246.3
Non-Polymers*	Number of molecules	5
	Total formula weight	628.8
All*	Total formula weight	185875.1

*Water molecules are not included.