6OPT

HIV-1 Protease NL4-3 V82F, I84V Mutant in complex with darunavir

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	B, A	Protease NL4-3	polymer	99	10865.9	2	UniProt (Q7ZCI0) Pfam (PF00077) In PDB	Human immunodeficiency virus 1
2	A	(3R,3AS,6AR)-HEXAHYDROFURO[2,3-B]FURAN-3-YL(1S,2R)-3-[[(4-AMINOPHENYL)SULFONYL](ISOBUTYL)AMINO]-1-BENZYL-2-HYDROXYPROPYLCARBAMATE	non-polymer		547.7	1	Chemie (017)
3	A	SULFATE ION	non-polymer		96.1	2	Chemie (SO4)
4		water	water		18.0	142	Chemie (HOH)

Sequence modifications

B, A: 1 - 99 (UniProt: Q7ZCI0)

PDB	External Database	Details
Lys 7	Gln 7	engineered mutation
Phe 82	Val 82	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	21731.7
Non-Polymers*	Number of molecules	3
	Total formula weight	739.8
All*	Total formula weight	22471.5

*Water molecules are not included.