6NMY
A Cytokine-receptor complex
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | F, M | Interleukin-3 receptor subunit alpha | polymer | 288 | 33225.5 | 2 | UniProt (P26951) Pfam (PF18611) Pfam (PF09240) In PDB | Homo sapiens (Human) | IL-3RA |
| 2 | A, C | Cytokine receptor common subunit beta | polymer | 216 | 24585.6 | 2 | UniProt (P32927) Pfam (PF21460) In PDB | Homo sapiens (Human) | CDw131,GM-CSF/IL-3/IL-5 receptor common beta subunit |
| 3 | I, J | Interleukin-3 | polymer | 118 | 13382.3 | 2 | UniProt (P08700) Pfam (PF02059) In PDB | Homo sapiens (Human) | IL-3,Hematopoietic growth factor,Mast cell growth factor,MCGF,Multipotential colony-stimulating factor,P-cell-stimulating factor |
| 4 | B, D | Cytokine receptor common subunit beta | polymer | 198 | 22691.2 | 2 | UniProt (P32927) In PDB | Homo sapiens (Human) | CDw131,GM-CSF/IL-3/IL-5 receptor common beta subunit |
| 5 | E, G | beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 732.7 | 2 | In PDB GlyTouCan (G32152BH) | |||
| 6 | H, K, N | beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 586.5 | 3 | In PDB GlyTouCan (G15407YE) | |||
| 7 | L, O | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 2 | In PDB GlyTouCan (G42666HT) | |||
| 8 | C | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 1 | Chemie (NAG) | |||
| 9 | water | water | 18.0 | 12 | Chemie (HOH) |
Sequence modifications
F, M: 20 - 307 (UniProt: P26951)
I, J: 12 - 125 (UniProt: P08700)
B, D: 241 - 438 (UniProt: P32927)
| PDB | External Database | Details |
|---|---|---|
| Gln 212 | Asn 212 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Gly 8 | - | expression tag |
| Ala 9 | - | expression tag |
| Met 10 | - | expression tag |
| Gly 11 | - | expression tag |
| Tyr 13 | Trp 32 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Gln 346 | Asn 346 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 8 |
| Total formula weight | 187769.2 | |
| Branched | Number of molecules | 7 |
| Total formula weight | 4073.8 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 221.2 | |
| All* | Total formula weight | 192064.2 |
