6LZB

crystal structure of Human Methionine aminopeptidase (HsMetAP1b) in complex with AN-P2-5H-06

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Methionine aminopeptidase 1	polymer	329	36935.9	1	UniProt (P53582) Pfam (PF00557) In PDB	Homo sapiens (Human)	MetAP 1,Peptidase M 1
2	A	COBALT (II) ION	non-polymer		58.9	2	Chemie (CO)
3	A	1-[(3-methoxyphenyl)methyl]-~{N}-oxidanyl-pyrrolo[2,3-b]pyridine-5-carboxamide	non-polymer		297.3	1	Chemie (EYF)
4	A	GLYCEROL	non-polymer		92.1	3	Chemie (GOL)
5	A	SODIUM ION	non-polymer		23.0	1	Chemie (NA)
6	A	MAGNESIUM ION	non-polymer		24.3	1	Chemie (MG)
7		water	water		18.0	188	Chemie (HOH)

Sequence modifications

A: 90 - 393 (UniProt: P53582)

PDB	External Database	Details
Met 65	-	initiating methionine
Gly 66	-	expression tag
Ser 67	-	expression tag
Ser 68	-	expression tag
His 69	-	expression tag
His 70	-	expression tag
His 71	-	expression tag
His 72	-	expression tag
His 73	-	expression tag
His 74	-	expression tag
Ser 75	-	expression tag
Ser 76	-	expression tag
Gly 77	-	expression tag
Leu 78	-	expression tag
Val 79	-	expression tag
Pro 80	-	expression tag
Arg 81	-	expression tag
Gly 82	-	expression tag
Ser 83	-	expression tag
His 84	-	expression tag
Met 85	-	expression tag
Leu 86	-	expression tag
Glu 87	-	expression tag
Asp 88	-	expression tag
Pro 89	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	36935.9
Non-Polymers*	Number of molecules	8
	Total formula weight	738.8
All*	Total formula weight	37674.7

*Water molecules are not included.