6LXD

Pri-miRNA bound DROSHA-DGCR8 complex

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Ribonuclease 3	polymer	990	115390.6	1	UniProt (Q9NRR4) Pfam (PF14622) Pfam (PF00636) Pfam (PF00035) In PDB	Homo sapiens (Human)	Protein Drosha,Ribonuclease III,RNase III,p241
2	B, C	Microprocessor complex subunit DGCR8	polymer	773	86171.2	2	UniProt (Q8WYQ5) Pfam (PF00035) In PDB	Homo sapiens (Human)	DiGeorge syndrome critical region 8
3	D	RNA (102-mer)	polymer	102	32759.4	1		Homo sapiens	Pri-16-1m
4	A	ZINC ION	non-polymer		65.4	2	Chemie (ZN)

Sequence modifications

A: 391 - 1374 (UniProt: Q9NRR4)

PDB	External Database	Details
Gln 1045	Glu 1045	engineered mutation
Gln 1222	Glu 1222	engineered mutation
His 1375	-	expression tag
His 1376	-	expression tag
His 1377	-	expression tag
His 1378	-	expression tag
His 1379	-	expression tag
His 1380	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	320492.4
Non-Polymers*	Number of molecules	2
	Total formula weight	130.8
All*	Total formula weight	320623.2

*Water molecules are not included.