6L57

Crystal structure of the alpha gamma heterodimer of human IDH3 in complex with CIT , Mg and ATP binding at allosteric site.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial	polymer	342	36957.5	1	UniProt (P50213) Pfam (PF00180) In PDB	Homo sapiens (Human)	Isocitric dehydrogenase subunit alpha,NAD(+)-specific ICDH subunit alpha
2	B	Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial	polymer	357	39142.9	1	UniProt (P51553) Pfam (PF00180) In PDB	Homo sapiens (Human)	Isocitric dehydrogenase subunit gamma,NAD(+)-specific ICDH subunit gamma
3	A, B	MAGNESIUM ION	non-polymer		24.3	2	Chemie (MG)
4	B	CITRIC ACID	non-polymer		192.1	1	Chemie (CIT)
5	B	ADENOSINE-5'-TRIPHOSPHATE	non-polymer		507.2	1	Chemie (ATP)
6		water	water		18.0	125	Chemie (HOH)

Sequence modifications

A: 1 - 339 (UniProt: P50213)

PDB	External Database	Details
Met -2	-	initiating methionine
Gly -1	-	expression tag
Ser 0	-	expression tag

B: 1 - 354 (UniProt: P51553)

PDB	External Database	Details
Met -2	-	initiating methionine
Gly -1	-	expression tag
Ser 0	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	76100.3
Non-Polymers*	Number of molecules	4
	Total formula weight	747.9
All*	Total formula weight	76848.3

*Water molecules are not included.