6KMH

The crystal structure of CASK/Mint1 complex

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	Peripheral plasma membrane protein CASK	polymer	325	36682.5	2	UniProt (O14936) Pfam (PF00069) In PDB	Homo sapiens (Human)	hCASK,Calcium/calmodulin-dependent serine protein kinase,Protein lin-2 homolog
2	C, D	Amyloid-beta A4 precursor protein-binding family A member 1	polymer	66	7734.7	2	UniProt (O35430) In PDB	Rattus norvegicus (Rat)	Adapter protein X11alpha,Neuron-specific X11 protein,Neuronal Munc18-1-interacting protein 1,Mint-1
3	A, B	IODIDE ION	non-polymer		126.9	12	Chemie (IOD)
4	A, B	CHLORIDE ION	non-polymer		35.5	2	Chemie (CL)
5		water	water		18.0	126	Chemie (HOH)

Sequence modifications

A, B: 1 - 319 (UniProt: O14936)

PDB	External Database	Details
Gly -5	-	expression tag
Pro -4	-	expression tag
Gly -3	-	expression tag
Ser -2	-	expression tag
Glu -1	-	expression tag
Phe 0	-	expression tag

C, D: 338 - 397 (UniProt: O35430)

PDB	External Database	Details
Gly -5	-	expression tag
Pro -4	-	expression tag
Gly -3	-	expression tag
Ser -2	-	expression tag
Glu -1	-	expression tag
Phe 0	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	88834.3
Non-Polymers*	Number of molecules	14
	Total formula weight	1593.8
All*	Total formula weight	90428.0

*Water molecules are not included.