6KLA
Crystal structure of human c-KIT kinase domain in complex with compound 15a
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Mast/stem cell growth factor receptor Kit | polymer | 331 | 37669.6 | 1 | UniProt (P10721) Pfam (PF07714) In PDB | Homo sapiens (Human) | SCFR,Piebald trait protein,PBT,Proto-oncogene c-Kit,Tyrosine-protein kinase Kit,p145 c-kit,v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog |
| 2 | A | N-[6-(4-ethylpiperazin-1-yl)-2-methyl-pyrimidin-4-yl]-5-pyridin-4-yl-1,3-thiazol-2-amine | non-polymer | 381.5 | 1 | Chemie (DJX) | |||
| 3 | water | water | 18.0 | 47 | Chemie (HOH) |
Sequence modifications
A: 547 - 751 (UniProt: P10721)
A: 754 - 935 (UniProt: P10721)
A: 754 - 935 (UniProt: P10721)
| PDB | External Database | Details |
|---|---|---|
| Thr 752 | - | linker |
| Ser 753 | - | linker |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 37669.6 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 381.5 | |
| All* | Total formula weight | 38051.1 |
