6KJV
Structure of thermal-stabilised(M9) human GLP-1 receptor transmembrane domain
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | Glucagon-like peptide 1 receptor,Endolysin,Glucagon-like peptide 1 receptor | polymer | 455 | 52583.3 | 2 | UniProt (P43220) UniProt (P00720) Pfam (PF00002) Pfam (PF00959) In PDB | Homo sapiens (Human) | GLP-1R,Lysis protein,Lysozyme,Muramidase,GLP-1R |
2 | A, B | N-{4-[(R)-(3,3-dimethylcyclobutyl)({6-[4-(trifluoromethyl)-1H-imidazol-1-yl]pyridin-3-yl}amino)methyl]benzene-1-carbonyl}-beta-alanine | non-polymer | 515.5 | 2 | Chemie (97Y) | |||
3 | A, B | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate | non-polymer | 356.5 | 2 | Chemie (OLC) | |||
4 | water | water | 18.0 | 8 | Chemie (HOH) |
Sequence modifications
A, B: 128 - 257 (UniProt: P43220)
A, B: 1001 - 1160 (UniProt: P00720)
A, B: 261 - 431 (UniProt: P43220)
PDB | External Database | Details |
---|---|---|
Ser 127 | - | expression tag |
Cys 193 | Ser 193 | engineered mutation |
Phe 196 | Ile 196 | engineered mutation |
- | Tyr 205 | deletion |
- | Ser 206 | deletion |
- | Thr 207 | deletion |
- | Ala 208 | deletion |
- | Ala 209 | deletion |
- | Gln 210 | deletion |
- | Gln 211 | deletion |
- | His 212 | deletion |
- | Gln 213 | deletion |
- | Trp 214 | deletion |
Gly 212 | - | linker |
Ser 213 | - | linker |
Gly 214 | - | linker |
Ala 225 | Ser 225 | engineered mutation |
PDB | External Database | Details |
---|---|---|
Gly 1011 | Arg 12 | engineered mutation |
Thr 1053 | Cys 54 | engineered mutation |
Ala 1096 | Cys 97 | engineered mutation |
Arg 1136 | Ile 137 | engineered mutation |
PDB | External Database | Details |
---|---|---|
Ala 271 | Ser 271 | engineered mutation |
Cys 317 | Ile 317 | engineered mutation |
Ile 318 | Gly 318 | engineered mutation |
Ala 346 | Lys 346 | engineered mutation |
Phe 347 | Cys 347 | engineered mutation |
Cys 361 | Gly 361 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 105166.6 | |
Non-Polymers* | Number of molecules | 4 |
Total formula weight | 1744.1 | |
All* | Total formula weight | 106910.7 |