6ITM
Crystal structure of FXR in complex with agonist XJ034
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, C | Bile acid receptor | polymer | 240 | 27949.1 | 2 | UniProt (Q96RI1) Pfam (PF00104) In PDB | Homo sapiens (Human) | Farnesoid X-activated receptor,Farnesol receptor HRR-1,Nuclear receptor subfamily 1 group H member 4,Retinoid X receptor-interacting protein 14,RXR-interacting protein 14 |
2 | B, D | HD3 Peptide from Nuclear receptor coactivator 1 | polymer | 14 | 1790.0 | 2 | UniProt (Q15788) In PDB | Homo sapiens | SRC-1 HD3 |
3 | A, C | 1-adamantyl-[4-(5-chloranyl-2-methyl-phenyl)piperazin-1-yl]methanone | non-polymer | 372.9 | 2 | Chemie (AWL) | |||
4 | water | water | 18.0 | 33 | Chemie (HOH) |
Sequence modifications
A, C: 257 - 486 (UniProt: Q96RI1)
PDB | External Database | Details |
---|---|---|
Met 247 | - | expression tag |
Gly 248 | - | expression tag |
His 249 | - | expression tag |
His 250 | - | expression tag |
His 251 | - | expression tag |
His 252 | - | expression tag |
His 253 | - | expression tag |
His 254 | - | expression tag |
Gly 255 | - | expression tag |
Ser 256 | - | expression tag |
Ala 291 | Glu 291 | engineered mutation |
Ala 364 | Glu 364 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 4 |
Total formula weight | 59478.2 | |
Non-Polymers* | Number of molecules | 2 |
Total formula weight | 745.9 | |
All* | Total formula weight | 60224.1 |