6I8S
Discovery and characterisation of an antibody that selectively modulates the inhibitory activity of plasminogen activator inhibitor-1
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D | Plasminogen activator inhibitor 1 | polymer | 379 | 42782.0 | 4 | UniProt (P05121) Pfam (PF00079) In PDB | Homo sapiens (Human) | PAI-1,Endothelial plasminogen activator inhibitor,Serpin E1 |
| 2 | E, F, G, H | HEAVY CHAIN OF FAB FRAGMENT FROM AN PAI-1 ANTIBODY | polymer | 223 | 23719.6 | 4 | Homo sapiens | ||
| 3 | I, J, K, L | LIGHT CHAIN OF FAB FRAGMENT FROM AN PAI-1 ANTIBODY | polymer | 214 | 23439.1 | 4 | Homo sapiens | ||
| 4 | water | water | 18.0 | 46 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 1 - 379 (UniProt: P05121)
| PDB | External Database | Details |
|---|---|---|
| His 150 | Asn 173 | engineered mutation |
| Thr 154 | Lys 177 | engineered mutation |
| Leu 319 | Gln 342 | engineered mutation |
| Ile 354 | Met 377 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 12 |
| Total formula weight | 359762.7 | |
| All* | Total formula weight | 359762.7 |
