6I5H
Crystal structure of CLK1 in complex with furanopyrimidin VN412
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Dual specificity protein kinase CLK1 | polymer | 339 | 39581.5 | 1 | UniProt (P49759) Pfam (PF00069) In PDB | Homo sapiens (Human) | CDC-like kinase 1 |
2 | A | 1,2-ETHANEDIOL | non-polymer | 62.1 | 5 | Chemie (EDO) | |||
3 | A | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
4 | A | 5-(1-methylpyrazol-4-yl)-3-(3-phenoxyphenyl)furo[3,2-b]pyridine | non-polymer | 367.4 | 1 | Chemie (H3N) | |||
5 | water | water | 18.0 | 271 | Chemie (HOH) |
Sequence modifications
A: 148 - 484 (UniProt: P49759)
PDB | External Database | Details |
---|---|---|
Ser 146 | - | expression tag |
Met 147 | - | expression tag |
Ala 432 | Arg 432 | variant |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 1 |
Total formula weight | 39581.5 | |
Non-Polymers* | Number of molecules | 7 |
Total formula weight | 769.8 | |
All* | Total formula weight | 40351.3 |