6GNU

Crystal Structure of Leishmania major N-Myristoyltransferase (NMT) With Bound Myristoyl-CoA and a Quionlinyl aryl sulphonamide ligand

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Glycylpeptide N-tetradecanoyltransferase	polymer	438	50513.3	1	UniProt (Q4Q5S8) Pfam (PF01233) Pfam (PF02799) In PDB	Leishmania major
2	A	TETRADECANOYL-COA	non-polymer		977.9	1	Chemie (MYA)
3	A	4-[4-(1-methylpiperidin-4-yl)butyl]-~{N}-[6-(2-methylpropyl)quinolin-5-yl]benzenesulfonamide	non-polymer		493.7	1	Chemie (F5Z)
4		water	water		18.0	270	Chemie (HOH)

Sequence modifications

A: 5 - 421 (UniProt: Q4Q5S8)

PDB	External Database	Details
Met -16	-	initiating methionine
Gly -15	-	expression tag
Ser -14	-	expression tag
Ser -13	-	expression tag
His -12	-	expression tag
His -11	-	expression tag
His -10	-	expression tag
His -9	-	expression tag
His -8	-	expression tag
His -7	-	expression tag
Ser -6	-	expression tag
Ser -5	-	expression tag
Gly -4	-	expression tag
Arg -3	-	expression tag
Glu -2	-	expression tag
Asn -1	-	expression tag
Leu 0	-	expression tag
Tyr 1	-	expression tag
Phe 2	-	expression tag
Gln 3	-	expression tag
Gly 4	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	50513.3
Non-Polymers*	Number of molecules	2
	Total formula weight	1471.6
All*	Total formula weight	51984.8

*Water molecules are not included.