6GHD

Structural analysis of the ternary complex between lamin A/C, BAF and emerin identifies an interface disrupted in autosomal recessive progeroid diseases

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	G, H	Emerin	polymer	45	5324.9	2	UniProt (P50402) Pfam (PF03020) In PDB	Homo sapiens (Human)
2	D, E, A, C	Barrier-to-autointegration factor	polymer	88	9814.1	4	UniProt (O75531) Pfam (PF02961) In PDB	Homo sapiens (Human)	Breakpoint cluster region protein 1
3	B, F	Prelamin-A/C	polymer	119	13206.8	2	UniProt (P02545) Pfam (PF00932) In PDB	Homo sapiens (Human)
4	G, D, E, A, C...	SULFATE ION	non-polymer		96.1	8	Chemie (SO4)
5	A	1,2-ETHANEDIOL	non-polymer		62.1	1	Chemie (EDO)
6		water	water		18.0	280	Chemie (HOH)

Sequence modifications

G, H: 2 - 45 (UniProt: P50402)

PDB	External Database	Details
Gly 1	-	expression tag

D, E, A, C: 2 - 89 (UniProt: O75531)

PDB	External Database	Details
Ala 67	Cys 67	engineered mutation
Ala 77	Cys 77	engineered mutation
Ala 80	Cys 80	engineered mutation
Ala 85	Cys 85	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	8
	Total formula weight	76319.9
Non-Polymers*	Number of molecules	9
	Total formula weight	830.6
All*	Total formula weight	77150.5

*Water molecules are not included.