6GFF
Structure of GARP (LRRC32) in complex with latent TGF-beta1 and MHG-8 Fab
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, C, E, G | Transforming growth factor beta-1 | polymer | 249 | 28531.5 | 4 | UniProt (P01137) Pfam (PF00688) In PDB | Homo sapiens (Human) | TGF-beta-1 |
2 | B, D, F, H | Transforming growth factor beta-1 | polymer | 112 | 12809.8 | 4 | UniProt (P01137) Pfam (PF00019) In PDB | Homo sapiens (Human) | TGF-beta-1 |
3 | I, J | Leucine-rich repeat-containing protein 32 | polymer | 618 | 67235.6 | 2 | UniProt (Q14392) Pfam (PF01462) Pfam (PF13855) In PDB | Homo sapiens (Human) | Garpin,Glycoprotein A repetitions predominant,GARP |
4 | K, M | MHG-8 Fab light chain | polymer | 212 | 23376.8 | 2 | Mus musculus (Mouse) | ||
5 | L, N | MHG-8 Fab heavy chain | polymer | 221 | 23832.6 | 2 | Mus musculus | ||
6 | O, P, Q, S, T | beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 586.5 | 5 | In PDB GlyTouCan (G15407YE) | |||
7 | R | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 1 | In PDB GlyTouCan (G42666HT) | |||
8 | U | alpha-D-mannopyranose-(1-6)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 748.7 | 1 | In PDB GlyTouCan (G22573RC) |
Sequence modifications
I, J: 20 - 628 (UniProt: Q14392)
PDB | External Database | Details |
---|---|---|
Glu 629 | - | expression tag |
Ala 630 | - | expression tag |
Ala 631 | - | expression tag |
Glu 632 | - | expression tag |
Asn 633 | - | expression tag |
Leu 634 | - | expression tag |
Tyr 635 | - | expression tag |
Phe 636 | - | expression tag |
Gln 637 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 14 |
Total formula weight | 394255.1 | |
Branched | Number of molecules | 7 |
Total formula weight | 4105.8 | |
All* | Total formula weight | 398360.9 |