6FUG
Complement factor D in complex with the inhibitor 3-((3-((3-(aminomethyl)phenyl)amino)-1H-pyrazolo[3,4-d]pyrimidin-4-yl)amino)phenol
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D, E... | Complement factor D | polymer | 232 | 24739.1 | 6 | UniProt (P00746) Pfam (PF00089) In PDB | Homo sapiens (Human) | Adipsin,C3 convertase activator,Properdin factor D |
| 2 | A, B, C, D, E... | 3-[[3-[[3-(aminomethyl)phenyl]amino]-1~{H}-pyrazolo[3,4-d]pyrimidin-4-yl]amino]phenol | non-polymer | 347.4 | 6 | Chemie (E85) | |||
| 3 | water | water | 18.0 | 285 | Chemie (HOH) |
Sequence modifications
A, B, C, D, E, F: 16 - 243 (UniProt: P00746)
| PDB | External Database | Details |
|---|---|---|
| Ser 244 | - | expression tag |
| Ala 245 | - | expression tag |
| Ala 246 | - | expression tag |
| Ala 247 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 148434.7 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 2084.2 | |
| All* | Total formula weight | 150519.0 |
