6EZ9
X-ray structure of human glutamate carboxypeptidase II (GCPII) - the E424M inactive mutant, in complex with a inhibitor JHU3372
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Glutamate carboxypeptidase 2 | polymer | 707 | 79616.8 | 1 | UniProt (Q04609) Pfam (PF02225) Pfam (PF04389) Pfam (PF04253) In PDB | Homo sapiens (Human) | Cell growth-inhibiting gene 27 protein,Folate hydrolase 1,Folylpoly-gamma-glutamate carboxypeptidase,FGCP,Glutamate carboxypeptidase II,GCPII,Membrane glutamate carboxypeptidase,mGCP,N-acetylated-alpha-linked acidic dipeptidase I,NAALADase I,Prostate-specific membrane antigen,PSMA,Pteroylpoly-gamma-glutamate carboxypeptidase |
| 2 | B, C | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 2 | In PDB GlyTouCan (G42666HT) | |||
| 3 | D | beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 586.5 | 1 | In PDB GlyTouCan (G15407YE) | |||
| 4 | E | alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 910.8 | 1 | In PDB GlyTouCan (G22768VO) | |||
| 5 | A | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 3 | Chemie (NAG) | |||
| 6 | A | ZINC ION | non-polymer | 65.4 | 2 | Chemie (ZN) | |||
| 7 | A | CALCIUM ION | non-polymer | 40.1 | 1 | Chemie (CA) | |||
| 8 | A | CHLORIDE ION | non-polymer | 35.5 | 1 | Chemie (CL) | |||
| 9 | A | (2~{S})-2-[[(2~{S})-4-methyl-1-oxidanyl-1-oxidanylidene-pentan-2-yl]oxycarbonylamino]pentanedioic acid | non-polymer | 305.3 | 1 | Chemie (C68) | |||
| 10 | water | water | 18.0 | 567 | Chemie (HOH) |
Sequence modifications
A: 44 - 750 (UniProt: Q04609)
| PDB | External Database | Details |
|---|---|---|
| Met 424 | Glu 424 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 79616.8 | |
| Branched | Number of molecules | 4 |
| Total formula weight | 2346.2 | |
| Non-Polymers* | Number of molecules | 8 |
| Total formula weight | 1175.3 | |
| All* | Total formula weight | 83138.2 |
