6EKD
Crystal structure of JNK3 in complex with a pyridinylimidazole inhibitor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Mitogen-activated protein kinase 10 | polymer | 367 | 42260.9 | 1 | UniProt (P53779) Pfam (PF00069) In PDB | Homo sapiens (Human) | MAPK 10,MAP kinase p49 3F12,Stress-activated protein kinase 1b,SAPK1b,Stress-activated protein kinase JNK3,c-Jun N-terminal kinase 3 |
| 2 | A | BETA-MERCAPTOETHANOL | non-polymer | 78.1 | 1 | Chemie (BME) | |||
| 3 | A | 1,2-ETHANEDIOL | non-polymer | 62.1 | 1 | Chemie (EDO) | |||
| 4 | A | 4-(4-methyl-2-methylsulfanyl-1~{H}-imidazol-5-yl)-~{N}-(4-morpholin-4-ylphenyl)pyridin-2-amine | non-polymer | 381.5 | 1 | Chemie (B9K) | |||
| 5 | water | water | 18.0 | 104 | Chemie (HOH) |
Sequence modifications
A: 39 - 402 (UniProt: P53779)
| PDB | External Database | Details |
|---|---|---|
| Gly 36 | - | expression tag |
| Gly 37 | - | expression tag |
| Ser 38 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 42260.9 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 521.7 | |
| All* | Total formula weight | 42782.6 |
