6EGS
Crystal structure of the GalNAc-T2 F104S mutant in complex with UDP-GalNAc
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B | Polypeptide N-acetylgalactosaminyltransferase 2 | polymer | 503 | 57370.1 | 2 | UniProt (Q10471) Pfam (PF00535) Pfam (PF00652) In PDB | Homo sapiens (Human) | Polypeptide GalNAc transferase 2,pp-GaNTase 2,Protein-UDP acetylgalactosaminyltransferase 2,UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 2 |
| 2 | A, B | MANGANESE (II) ION | non-polymer | 54.9 | 2 | Chemie (MN) | |||
| 3 | A, B | URIDINE-DIPHOSPHATE-N-ACETYLGALACTOSAMINE | non-polymer | 607.4 | 2 | Chemie (UD2) | |||
| 4 | water | water | 18.0 | 60 | Chemie (HOH) |
Sequence modifications
A, B: 75 - 571 (UniProt: Q10471)
| PDB | External Database | Details |
|---|---|---|
| Lys 69 | - | expression tag |
| Arg 70 | - | expression tag |
| Glu 71 | - | expression tag |
| Ala 72 | - | expression tag |
| Glu 73 | - | expression tag |
| Ala 74 | - | expression tag |
| Ser 104 | Phe 104 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 114740.2 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 1324.6 | |
| All* | Total formula weight | 116064.8 |
