6DQD

LINKED KDM5A JMJ DOMAIN BOUND TO THE INHIBITOR N53 i.e. 2-(5-([1,1'-biphenyl]-3-yl)-4-(1-(2-(piperidin-1-yl)ethoxy)ethyl)-1H-pyrazol-1-yl)isonicotinic acid

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Linked KDM5A Jmj Domain	polymer	330	37944.8	1	UniProt (P29375) Pfam (PF02375) Pfam (PF02373) In PDB	Homo sapiens (Human)	Histone demethylase JARID1A,Jumonji/ARID domain-containing protein 1A,Retinoblastoma-binding protein 2,RBBP-2,Histone demethylase JARID1A,Jumonji/ARID domain-containing protein 1A,Retinoblastoma-binding protein 2,RBBP-2
2	A	2-[5-([1,1'-biphenyl]-3-yl)-4-{(1S)-1-[2-(piperidin-1-yl)ethoxy]ethyl}-1H-pyrazol-1-yl]pyridine-4-carboxylic acid	non-polymer		496.6	1	Chemie (H67)
3	A	MANGANESE (II) ION	non-polymer		54.9	1	Chemie (MN)
4	A	GLYCEROL	non-polymer		92.1	2	Chemie (GOL)
5	A	DIMETHYL SULFOXIDE	non-polymer		78.1	2	Chemie (DMS)
6		water	water		18.0	167	Chemie (HOH)

Sequence modifications

A: 1 - 347 (UniProt: P29375)

PDB	External Database	Details
His -1	-	expression tag
Asn 0	-	expression tag

A: 348 - 588 (UniProt: P29375)

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	37944.8
Non-Polymers*	Number of molecules	6
	Total formula weight	892.0
All*	Total formula weight	38836.8

*Water molecules are not included.