6DB0
N-Terminal bromodomain of Human BRD2 with a Tetrahydroquinoline analogue
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C | Bromodomain-containing protein 2 | polymer | 138 | 16150.8 | 3 | UniProt (P25440) Pfam (PF00439) In PDB | Homo sapiens (Human) | O27.1.1,Really interesting new gene 3 protein |
| 2 | A | SULFATE ION | non-polymer | 96.1 | 1 | Chemie (SO4) | |||
| 3 | A, B | 1-[(2S,4R)-4-[(2-chlorophenyl)amino]-2-methyl-6-(1H-pyrazol-3-yl)-3,4-dihydroquinolin-1(2H)-yl]ethan-1-one | non-polymer | 380.9 | 2 | Chemie (G3J) | |||
| 4 | B | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID | non-polymer | 238.3 | 1 | Chemie (EPE) | |||
| 5 | C | 1,2-ETHANEDIOL | non-polymer | 62.1 | 1 | Chemie (EDO) | |||
| 6 | water | water | 18.0 | 202 | Chemie (HOH) |
Sequence modifications
A, B, C: 67 - 200 (UniProt: P25440)
| PDB | External Database | Details |
|---|---|---|
| Gly 63 | - | expression tag |
| Ser 64 | - | expression tag |
| His 65 | - | expression tag |
| Met 66 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 48452.5 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 1158.2 | |
| All* | Total formula weight | 49610.7 |
