6DAF

2.4 Angstrom crystal structure of the F141L Ca/CaM:CaV1.2 IQ domain complex

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	Calmodulin-1	polymer	148	16687.3	2	UniProt (P0DP23) Pfam (PF13499) In PDB	Homo sapiens (Human)
2	C, D	Voltage-dependent L-type calcium channel subunit alpha-1C	polymer	37	4319.0	2	UniProt (Q13936) In PDB	Homo sapiens (Human)	Calcium channel, L type, alpha-1 polypeptide, isoform 1, cardiac muscle, Voltage-gated calcium channel subunit alpha Cav1.2
3	A, B	CALCIUM ION	non-polymer		40.1	8	Chemie (CA)
4		water	water		18.0	19	Chemie (HOH)

Sequence modifications

A, B: 1 - 148 (UniProt: P0DP23)

PDB	External Database	Details
Leu 141	Phe 142	engineered mutation

C, D: 1611 - 1644 (UniProt: Q13936)

PDB	External Database	Details
Ser 1608	-	expression tag
Asn 1609	-	expression tag
Ala 1610	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	42012.6
Non-Polymers*	Number of molecules	8
	Total formula weight	320.6
All*	Total formula weight	42333.2

*Water molecules are not included.