6CRK
Heterotrimeric G-protein in complex with an antibody fragment
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Guanine nucleotide-binding protein G(i) subunit alpha-1 | polymer | 355 | 40438.0 | 1 | UniProt (P63096) Pfam (PF00503) In PDB | Homo sapiens (Human) | Adenylate cyclase-inhibiting G alpha protein |
2 | B | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | polymer | 345 | 37728.2 | 1 | UniProt (P62873) Pfam (PF00400) In PDB | Homo sapiens (Human) | Transducin beta chain 1 |
3 | G | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 | polymer | 71 | 7845.1 | 1 | UniProt (P59768) Pfam (PF00631) In PDB | Homo sapiens (Human) | G gamma-I |
4 | H | single-chain Fv | polymer | 259 | 27784.9 | 1 | Mus musculus (mouse) | ||
5 | A | GUANOSINE-5'-DIPHOSPHATE | non-polymer | 443.2 | 1 | Chemie (GDP) | |||
6 | A | CITRATE ANION | non-polymer | 189.1 | 1 | Chemie (FLC) | |||
7 | water | water | 18.0 | 627 | Chemie (HOH) |
Sequence modifications
A: 2 - 354 (UniProt: P63096)
B: 2 - 340 (UniProt: P62873)
G: 1 - 71 (UniProt: P59768)
PDB | External Database | Details |
---|---|---|
Gly 0 | - | expression tag |
Pro 1 | - | expression tag |
PDB | External Database | Details |
---|---|---|
Gly -4 | - | expression tag |
Pro -3 | - | expression tag |
Gly -2 | - | expression tag |
Ser -1 | - | expression tag |
Ser 0 | - | expression tag |
Gly 1 | - | expression tag |
PDB | External Database | Details |
---|---|---|
Ser 68 | Cys 68 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 4 |
Total formula weight | 113796.1 | |
Non-Polymers* | Number of molecules | 2 |
Total formula weight | 632.3 | |
All* | Total formula weight | 114428.4 |