6C0L
Crystal structure of HIV-1 E138K mutant reverse transcriptase in complex with non-nucleoside inhibitor K-5a2
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Reverse transcriptase/ribonuclease H | polymer | 557 | 63989.2 | 1 | UniProt (P03366) Pfam (PF00078) Pfam (PF06817) Pfam (PF06815) Pfam (PF00075) In PDB | Human immunodeficiency virus type 1 group M subtype B (isolate BH10) | Pr160Gag-Pol |
2 | B | Reverse transcriptase p51 subunit | polymer | 428 | 50039.6 | 1 | UniProt (P03366) Pfam (PF00078) Pfam (PF06817) Pfam (PF06815) In PDB | Human immunodeficiency virus type 1 group M subtype B (isolate BH10) | Pr160Gag-Pol |
3 | A | 4-[(4-{[4-(4-cyano-2,6-dimethylphenoxy)thieno[3,2-d]pyrimidin-2-yl]amino}piperidin-1-yl)methyl]benzene-1-sulfonamide | non-polymer | 548.7 | 1 | Chemie (K5A) | |||
4 | A | MAGNESIUM ION | non-polymer | 24.3 | 1 | Chemie (MG) | |||
5 | A | SODIUM ION | non-polymer | 23.0 | 1 | Chemie (NA) | |||
6 | B, A | SULFATE ION | non-polymer | 96.1 | 8 | Chemie (SO4) | |||
7 | B, A | 1,2-ETHANEDIOL | non-polymer | 62.1 | 26 | Chemie (EDO) | |||
8 | water | water | 18.0 | 746 | Chemie (HOH) |
Sequence modifications
A: 1 - 555 (UniProt: P03366)
B: 1 - 428 (UniProt: P03366)
PDB | External Database | Details |
---|---|---|
Met -1 | - | initiating methionine |
Val 0 | - | expression tag |
Ala 172 | Lys 771 | engineered mutation |
Ala 173 | Lys 772 | engineered mutation |
Ser 280 | Cys 879 | engineered mutation |
PDB | External Database | Details |
---|---|---|
Lys 138 | Glu 737 | engineered mutation |
Ser 280 | Cys 879 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 114028.8 | |
Non-Polymers* | Number of molecules | 37 |
Total formula weight | 2978.2 | |
All* | Total formula weight | 117007.0 |