6BY8
Menin in complex with MI-1482
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Menin | polymer | 489 | 54600.2 | 1 | UniProt (O00255) Pfam (PF05053) In PDB | Homo sapiens (Human) | |
2 | A | 4-methyl-1-{[(2R)-5-oxomorpholin-2-yl]methyl}-5-[(4-{[6-(2,2,2-trifluoroethyl)thieno[2,3-d]pyrimidin-4-yl]amino}piperidin-1-yl)methyl]-1H-indole-2-carbonitrile | non-polymer | 597.7 | 1 | Chemie (FNV) | |||
3 | A | DIMETHYL SULFOXIDE | non-polymer | 78.1 | 4 | Chemie (DMS) | |||
4 | A | TETRAETHYLENE GLYCOL | non-polymer | 194.2 | 2 | Chemie (PG4) | |||
5 | A | SULFATE ION | non-polymer | 96.1 | 2 | Chemie (SO4) | |||
6 | A | 1,2-ETHANEDIOL | non-polymer | 62.1 | 1 | Chemie (EDO) | |||
7 | water | water | 18.0 | 456 | Chemie (HOH) |
Sequence modifications
A: 1 - 53 (UniProt: O00255)
A: 74 - 386 (UniProt: O00255)
A: 399 - 459 (UniProt: O00255)
A: 460 - 593 (UniProt: O00255)
PDB | External Database | Details |
---|---|---|
Gly -4 | - | expression tag |
Gly -3 | - | expression tag |
Ser -2 | - | expression tag |
Ser -1 | - | expression tag |
Ser 0 | - | expression tag |
A: 399 - 459 (UniProt: O00255)
A: 460 - 593 (UniProt: O00255)
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 1 |
Total formula weight | 54600.2 | |
Non-Polymers* | Number of molecules | 10 |
Total formula weight | 1552.8 | |
All* | Total formula weight | 56153.1 |