6BU0
Crystal structure of the PI3KC2alpha C2 domain in complex with IP6
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C | Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha | polymer | 131 | 14872.1 | 3 | UniProt (O00443) Pfam (PF00168) In PDB | Homo sapiens (Human) | PtdIns-3-kinase C2 subunit alpha,Phosphoinositide 3-kinase-C2-alpha |
| 2 | A, B | FORMIC ACID | non-polymer | 46.0 | 5 | Chemie (FMT) | |||
| 3 | B, C | INOSITOL HEXAKISPHOSPHATE | non-polymer | 660.0 | 4 | Chemie (IHP) | |||
| 4 | C | 1,4,7,10,13,16-HEXAOXACYCLOOCTADECANE | non-polymer | 264.3 | 1 | Chemie (O4B) | |||
| 5 | water | water | 18.0 | 23 | Chemie (HOH) |
Sequence modifications
A, B, C: 1559 - 1686 (UniProt: O00443)
| PDB | External Database | Details |
|---|---|---|
| Ser 1556 | - | expression tag |
| Asn 1557 | - | expression tag |
| Ala 1558 | - | expression tag |
| Gly 1654 | Glu 1654 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 44616.3 | |
| Non-Polymers* | Number of molecules | 10 |
| Total formula weight | 3134.6 | |
| All* | Total formula weight | 47750.9 |
