6BKS

Crystal structure of the A/Wyoming/3/2003 (H3N2) influenza virus hemagglutinin D190E mutant in complex with 6'-SLN

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Hemagglutinin	polymer	323	35888.5	1	UniProt (A4GYF9) Pfam (PF00509) In PDB	Influenza A virus (A/Wyoming/3e/2003(H3))
2	B	Hemagglutinin	polymer	174	20040.2	1	UniProt (B4UPH9) Pfam (PF00509) In PDB	Influenza A virus (A/Nymc X-149C6(Puerto Rico/8/1934-Wyoming/03/2003)(H3N2))
3	C	beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		586.5	1	In PDB GlyTouCan (G15407YE)
4	D	alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		910.8	1	In PDB GlyTouCan (G22768VO)
5	E, F	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		424.4	2	In PDB GlyTouCan (G42666HT)
6	A, B	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	4	Chemie (NAG)
7	A	N-acetyl-alpha-neuraminic acid	non-polymer		309.3	1	Chemie (SIA)
8		water	water		18.0	523	Chemie (HOH)

Sequence modifications

A: 11 - 329 (UniProt: A4GYF9)

PDB	External Database	Details
Ala 7	-	expression tag
Asp 8	-	expression tag
Pro 9	-	expression tag
Gly 10	-	expression tag
Glu 190	Asp 190	engineered mutation
Phe 219	Ser 219	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	55928.7
Branched	Number of molecules	4
	Total formula weight	2346.2
Non-Polymers*	Number of molecules	5
	Total formula weight	1194.1
All*	Total formula weight	59469.0

*Water molecules are not included.