6B9P

Structure of GH 38 Jack Bean alpha-mannosidase in complex with a 36-valent iminosugar cluster inhibitor

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	Alpha-mannosidase from Canavalia ensiformis (jack bean)	polymer	981	111225.6	2	Pfam (PF01074) Pfam (PF09261) Pfam (PF07748) UniProt (by SIFTS) (C0HJB3) In PDB	Canavalia ensiformis
2	C, E	alpha-D-mannopyranose-(1-3)-alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-6)]alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		2045.8	2	In PDB GlyTouCan (G77969OS)
3	D, F	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		424.4	2	In PDB GlyTouCan (G42666HT)
4	A, B	(2R,3R,4R,5S)-2-(hydroxymethyl)-1-{9-[4-(methoxymethyl)-1H-1,2,3-triazol-1-yl]nonyl}piperidine-3,4,5-triol	non-polymer		400.5	2	Chemie (D0J)
5	A, B	ZINC ION	non-polymer		65.4	2	Chemie (ZN)
6		water	water		18.0	1367	Chemie (HOH)

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	222451.2
Branched	Number of molecules	4
	Total formula weight	4940.4
Non-Polymers*	Number of molecules	4
	Total formula weight	931.8
All*	Total formula weight	228323.5

*Water molecules are not included.