6B4U
Crystal structure of MCL-1 in complex with a BIM competitive inhibitor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Induced myeloid leukemia cell differentiation protein Mcl-1 | polymer | 157 | 17882.4 | 1 | UniProt (Q07820) Pfam (PF00452) In PDB | Homo sapiens (Human) | Bcl-2-like protein 3,Bcl2-L-3,Bcl-2-related protein EAT/mcl1,mcl1/EAT |
| 2 | A | 7-(2-methylphenyl)-1-[2-(morpholin-4-yl)ethyl]-3-{3-[(naphthalen-1-yl)oxy]propyl}-1H-indole-2-carboxylic acid | non-polymer | 548.7 | 1 | Chemie (CN7) | |||
| 3 | water | water | 18.0 | 108 | Chemie (HOH) |
Sequence modifications
A: 174 - 326 (UniProt: Q07820)
| PDB | External Database | Details |
|---|---|---|
| Gly 170 | - | expression tag |
| Ser 171 | - | expression tag |
| Met 172 | - | expression tag |
| Asp 173 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 17882.4 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 548.7 | |
| All* | Total formula weight | 18431.1 |
