5Z1D
MAP2K7 C276S mutant-inhibitor
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Dual specificity mitogen-activated protein kinase kinase 7 | polymer | 324 | 36982.8 | 1 | UniProt (O14733) Pfam (PF00069) In PDB | Homo sapiens (Human) | MAPKK 7,JNK-activating kinase 2,MAPK/ERK kinase 7,MEK 7,Stress-activated protein kinase kinase 4,SAPKK4,c-Jun N-terminal kinase kinase 2,JNKK 2 |
2 | A | N-[3-(6-methyl-1H-indazol-3-yl)phenyl]prop-2-enamide | non-polymer | 277.3 | 1 | Chemie (95U) | |||
3 | A | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID | non-polymer | 238.3 | 1 | Chemie (EPE) | |||
4 | water | water | 18.0 | 101 | Chemie (HOH) |
Sequence modifications
A: 119 - 435 (UniProt: O14733)
PDB | External Database | Details |
---|---|---|
Met 118 | - | initiating methionine |
Ser 276 | Cys 260 | conflict |
His 436 | - | expression tag |
His 437 | - | expression tag |
His 438 | - | expression tag |
His 439 | - | expression tag |
His 440 | - | expression tag |
His 441 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 1 |
Total formula weight | 36982.8 | |
Non-Polymers* | Number of molecules | 2 |
Total formula weight | 515.6 | |
All* | Total formula weight | 37498.5 |