5Y1J
Crystal structure of human FXR in complex with a functional drug ligand
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Bile acid receptor | polymer | 228 | 26609.6 | 1 | UniProt (Q96RI1) Pfam (PF00104) In PDB | Homo sapiens (Human) | Farnesoid X-activated receptor,Farnesol receptor HRR-1,Nuclear receptor subfamily 1 group H member 4,Retinoid X receptor-interacting protein 14,RXR-interacting protein 14 |
| 2 | U | Peptide from Nuclear receptor coactivator 2 | polymer | 10 | 1220.5 | 1 | UniProt (Q15596) In PDB | Homo sapiens | NCoA-2,Class E basic helix-loop-helix protein 75,bHLHe75,Transcriptional intermediary factor 2,hTIF2 |
| 3 | A | 2-[[2-fluoranyl-4-(3-methoxyphenyl)phenyl]carbamoyl]cyclopentene-1-carboxylic acid | non-polymer | 355.4 | 1 | Chemie (D5H) | |||
| 4 | water | water | 18.0 | 110 | Chemie (HOH) |
Sequence modifications
A: 244 - 471 (UniProt: Q96RI1)
| PDB | External Database | Details |
|---|---|---|
| Ala 277 | Glu 277 | conflict |
| Ala 350 | Glu 350 | conflict |
| Lys 432 | Cys 432 | conflict |
| Gln 466 | Cys 466 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 27830.1 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 355.4 | |
| All* | Total formula weight | 28185.4 |
