5Y19

Crystal structure of Plasmodium falciparum aminopeptidase N in complex with (S)-2-((2S,3R)-3-amino-2-hydroxy-4-phenylbutanamido)- N-hydroxy-4-methylpentanamide.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	M1 family aminopeptidase	polymer	914	106291.5	1	UniProt (O96935) Pfam (PF17900) Pfam (PF01433) Pfam (PF11940) Pfam (PF17432) In PDB	Plasmodium falciparum	Pfa-M1
2	A	ZINC ION	non-polymer		65.4	1	Chemie (ZN)
3	A	MAGNESIUM ION	non-polymer		24.3	2	Chemie (MG)
4	A	GLYCEROL	non-polymer		92.1	1	Chemie (GOL)
5	A	(2S)-2-[[(2S,3R)-3-azanyl-2-oxidanyl-4-phenyl-butanoyl]amino]-4-methyl-N-oxidanyl-pentanamide	non-polymer		323.4	1	Chemie (8KO)
6		water	water		18.0	399	Chemie (HOH)

Sequence modifications

A: 195 - 1085 (UniProt: O96935)

PDB	External Database	Details
Met 172	-	expression tag
Gly 173	-	expression tag
Ser 174	-	expression tag
Ser 175	-	expression tag
His 176	-	expression tag
His 177	-	expression tag
His 178	-	expression tag
His 179	-	expression tag
His 180	-	expression tag
His 181	-	expression tag
Ser 182	-	expression tag
Ser 183	-	expression tag
Gly 184	-	expression tag
Leu 185	-	expression tag
Val 186	-	expression tag
Pro 187	-	expression tag
Arg 188	-	expression tag
Gly 189	-	expression tag
Ser 190	-	expression tag
His 191	-	expression tag
Met 192	-	expression tag
Ala 193	-	expression tag
Ser 194	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	106291.5
Non-Polymers*	Number of molecules	5
	Total formula weight	529.5
All*	Total formula weight	106821.0

*Water molecules are not included.