5WIL
JAK2 Pseudokinase in complex with AZD7762
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Tyrosine-protein kinase JAK2 | polymer | 277 | 31681.4 | 1 | UniProt (O60674) Pfam (PF07714) In PDB | Homo sapiens (Human) | Janus kinase 2,JAK-2 |
2 | A | 5-(3-fluorophenyl)-N-[(3S)-3-piperidyl]-3-ureido-thiophene-2-carboxamide | non-polymer | 362.4 | 1 | Chemie (YDJ) | |||
3 | water | water | 18.0 | 92 | Chemie (HOH) |
Sequence modifications
A: 536 - 812 (UniProt: O60674)
PDB | External Database | Details |
---|---|---|
Ala 659 | Trp 659 | engineered mutation |
Ala 777 | Trp 777 | engineered mutation |
His 794 | Phe 794 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 1 |
Total formula weight | 31681.4 | |
Non-Polymers* | Number of molecules | 1 |
Total formula weight | 362.4 | |
All* | Total formula weight | 32043.8 |