5WEO

Activated GluA2 complex bound to glutamate, cyclothiazide, and STZ in digitonin

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D	Glutamate receptor 2,Voltage-dependent calcium channel gamma-2 subunit chimera	polymer	1034	115502.0	4	UniProt (P19491) UniProt (O88602) Pfam (PF01094) Pfam (PF10613) Pfam (PF00060) Pfam (PF00497) Pfam (PF00822) In PDB	Rattus norvegicus (Rat)	GluR-2,AMPA-selective glutamate receptor 2,GluR-B,GluR-K2,Glutamate receptor ionotropic,AMPA 2,GluA2,Neuronal voltage-gated calcium channel gamma-2 subunit,Stargazin,Transmembrane AMPAR regulatory protein gamma-2,TARP gamma-2
2	A, B, C, D	GLUTAMIC ACID	non-polymer		147.1	4	Chemie (GLU)
3	A, B, C, D	CYCLOTHIAZIDE	non-polymer		389.9	4	Chemie (CYZ)

Sequence modifications

A, B, C, D: 10 - 826 (UniProt: P19491)

PDB	External Database	Details
Glu 241	Asn 256	engineered mutation
Leu 382	Val 397	engineered mutation
-	Leu 399	deletion
-	Thr 400	deletion
-	Glu 401	deletion
-	Leu 402	deletion
-	Pro 403	deletion
-	Ser 404	deletion
Glu 384	Gly 405	engineered mutation
Asp 385	Asn 406	engineered mutation
Gln 392	Asn 413	engineered mutation
Gly 827	-	linker
Thr 828	-	linker

A, B, C, D: 1001 - 1207 (UniProt: O88602)

PDB	External Database	Details
Asp 1047	Asn 48	conflict
Thr 1208	-	expression tag
Gly 1209	-	expression tag
Gly 1210	-	expression tag
Leu 1211	-	expression tag
Val 1212	-	expression tag
Pro 1213	-	expression tag
Arg 1214	-	expression tag
Gly 1215	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	462007.9
Non-Polymers*	Number of molecules	8
	Total formula weight	2148.0
All*	Total formula weight	464155.9

*Water molecules are not included.