5W85
CRYSTAL STRUCTURE OF IRAK-4 WITH A 4,6-DIAMINONICOTINAMIDE INHIBITOR (COMPOUND NUMBER 9)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B | Interleukin-1 receptor-associated kinase 4 | polymer | 305 | 34272.6 | 2 | UniProt (Q9NWZ3) Pfam (PF07714) In PDB | Homo sapiens (Human) | IRAK-4,Renal carcinoma antigen NY-REN-64 |
| 2 | A, B | 6-[(1,3-benzothiazol-6-yl)amino]-4-{[(2S)-1-hydroxy-3-phenylpropan-2-yl]amino}-N-methylpyridine-3-carboxamide | non-polymer | 433.5 | 2 | Chemie (9YS) | |||
| 3 | water | water | 18.0 | 107 | Chemie (HOH) |
Sequence modifications
A, B: 160 - 460 (UniProt: Q9NWZ3)
| PDB | External Database | Details |
|---|---|---|
| Gly 156 | - | expression tag |
| Ala 157 | - | expression tag |
| Met 158 | - | expression tag |
| Gly 159 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 68545.1 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 867.1 | |
| All* | Total formula weight | 69412.2 |
