5UWC

Cytokine-receptor complex

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	G	Interleukin-3 receptor subunit alpha	polymer	288	33253.6	1	UniProt (P26951) Pfam (PF18611) Pfam (PF09240) In PDB	Homo sapiens (Human)	IL-3RA
2	I	Interleukin-3	polymer	122	13969.9	1	UniProt (P08700) Pfam (PF02059) In PDB	Homo sapiens (Human)	IL-3,Hematopoietic growth factor,Mast cell growth factor,MCGF,Multipotential colony-stimulating factor,P-cell-stimulating factor
3	A	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[beta-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose	branched		570.5	1	In PDB GlyTouCan (G28454KX)
4	G	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	1	Chemie (NAG)
5	G, I	CITRIC ACID	non-polymer		192.1	2	Chemie (CIT)
6	G	IMIDAZOLE	non-polymer		69.1	1	Chemie (IMD)
7	G	{[-(BIS-CARBOXYMETHYL-AMINO)-ETHYL]-CARBOXYMETHYL-AMINO}-ACETIC ACID	non-polymer		292.2	1	Chemie (EDT)
8		water	water		18.0	64	Chemie (HOH)

Sequence modifications

G: 20 - 307 (UniProt: P26951)

PDB	External Database	Details
Gln 212	Asn 212	engineered mutation
Val 299	Ala 299	engineered mutation

I: 12 - 133 (UniProt: P08700)

PDB	External Database	Details
Tyr 13	Trp 32	engineered mutation
Trp 116	Lys 135	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	47223.5
Branched	Number of molecules	1
	Total formula weight	570.5
Non-Polymers*	Number of molecules	5
	Total formula weight	966.8
All*	Total formula weight	48760.8

*Water molecules are not included.