5UFU
Structure of AMPK bound to activator
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | 5'-AMP-activated protein kinase catalytic subunit alpha-1 | polymer | 503 | 57779.1 | 1 | UniProt (P54645) UniProt (Q5EG47) Pfam (PF00069) Pfam (PF21147) Pfam (PF16579) In PDB | Rattus norvegicus (Rat) | AMPK subunit alpha-1,Acetyl-CoA carboxylase kinase,ACACA kinase,Hydroxymethylglutaryl-CoA reductase kinase,HMGCR kinase,Tau-protein kinase PRKAA1,AMPK subunit alpha-1,Acetyl-CoA carboxylase kinase,ACACA kinase,Hydroxymethylglutaryl-CoA reductase kinase,HMGCR kinase,Tau-protein kinase PRKAA1 |
| 2 | B | 5'-AMP-activated protein kinase subunit beta-1 | polymer | 204 | 23045.3 | 1 | UniProt (P80386) Pfam (PF16561) Pfam (PF04739) In PDB | Rattus norvegicus (Rat) | AMPKb,5'-AMP-activated protein kinase 40 kDa subunit |
| 3 | C | 5'-AMP-activated protein kinase subunit gamma-1 | polymer | 330 | 37434.1 | 1 | UniProt (P80385) Pfam (PF00571) In PDB | Rattus norvegicus (Rat) | AMPKg |
| 4 | A | STAUROSPORINE | non-polymer | 466.5 | 1 | Chemie (STU) | |||
| 5 | A | 1,4:3,6-dianhydro-2-O-(6-chloro-5-{4-[1-(hydroxymethyl)cyclopropyl]phenyl}-1H-benzimidazol-2-yl)-D-mannitol | non-polymer | 442.9 | 1 | Chemie (85V) | |||
| 6 | A | CHLORIDE ION | non-polymer | 35.5 | 3 | Chemie (CL) | |||
| 7 | A, C | SULFATE ION | non-polymer | 96.1 | 2 | Chemie (SO4) | |||
| 8 | C | ADENOSINE MONOPHOSPHATE | non-polymer | 347.2 | 2 | Chemie (AMP) | |||
| 9 | C | ADENOSINE-5'-DIPHOSPHATE | non-polymer | 427.2 | 1 | Chemie (ADP) |
Sequence modifications
A: 0 - 469 (UniProt: P54645)
A: 525 - 548 (UniProt: Q5EG47)
B: 68 - 270 (UniProt: P80386)
| PDB | External Database | Details |
|---|---|---|
| Gly -1 | - | expression tag |
| Ala 517 | - | see remark 999 |
| Ser 518 | - | see remark 999 |
| Gly 519 | - | see remark 999 |
| Gly 520 | - | see remark 999 |
| Pro 521 | - | see remark 999 |
| Gly 522 | - | see remark 999 |
| Gly 523 | - | see remark 999 |
| Ser 524 | - | see remark 999 |
B: 68 - 270 (UniProt: P80386)
| PDB | External Database | Details |
|---|---|---|
| Met 67 | - | initiating methionine |
| Asp 108 | Ser 108 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 118258.5 | |
| Non-Polymers* | Number of molecules | 10 |
| Total formula weight | 2329.6 | |
| All* | Total formula weight | 120588.1 |
